![]() ![]() These drugs, however, are associated with significant and occasionally debilitating side effects 2,3. Microtubule targeting drugs (e.g., Paclitaxel and Vincristine) are quite efficacious and continue to be a front line therapeutic approach for several cancers (e.g., ovarian, breast, gastroesophageal) 2. ![]() From a therapeutic standpoint, it was anticipated that inhibiting KSP would produce antimitotic benefits by targeting microtubules with fewer and less severe side effects. KSP plays a critical role in mitotic spindle pole separation, and its inhibition results in the formation of monoaster spindles which is thought to lead to mitotic catastrophe and apoptosis 1. The Kinesin Spindle Protein (KSP also known as Eg5 or KIF11) is a Kinesin-5 subfamily member and has been the focus of a significant drug development effort throughout the pharmaceutical industry for the last 15 years. KSP (Eg5) Inhibition - Theory and Expreimental Studies MemGlow™ Plasma Membrane Probes for Bioimaging 8.Small G-protein Activators & Inhibitors 5.GOBlot - The First Affordable Western Blot Processor. ![]()
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